Academic Textbook: Role of Vitamin D in Pathogenesis, Diagnosis, and Treatment of Inflammatory Diseases
Keywords:
Vitamin D, Pathogenesis, Diagnosis, Treatment, Inflammatory DiseasesAbstract
Vitamin D performs its immunomodulatory effects on T lymphocytes, by inhibiting the synthesis of pro-inflammatory Th1 cytokines (IL-1, IL-2, IL-6, IL-12, IFN-γ, TNF-α, and TNF-β), and triggering the synthesis of anti-inflammatory regulatory Th2 cytokines (IL-4, IL-5, and IL-10).
Therefore, vitamin D potentiates the innate immune system and regulates the adaptive immune system, mainly by triggering the split to Th2 and regulatory T cells (Tregs), over the Th1 and Th17 lymphocytes differentiation, via direct and indirect effects on naive CD4+ cells. The general finding is an evident effect of switching capacity, from a pro-inflammatory autoimmune to an anti-inflammatory tolerogenic immunological effect.
References
1. Dusso AS, Bauerle KT, Bernal-Mizrachi C. Non-classical Vitamin D Actions for Renal Protection. Front Med (Lausanne). 2021;8:790513.
2. Cianciolo G, Cappuccilli M, Tondolo F, Gasperoni L, Zappulo F, Barbuto S, et al. Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients. Nutrients. 2021;13(5).
3. Gembillo G, Cernaro V, Siligato R, Curreri F, Catalano A, Santoro D. Protective Role of Vitamin D in Renal Tubulopathies. Metabolites. 2020;10(3).
4. Wu J, Yang N, Yuan M. Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies. Int Braz J Urol. 2021;47(4):733-44.
5. Gangula PR, Dong YL, Al-Hendy A, Richard-Davis G, Montgomery-Rice V, Haddad G, et al. Protective cardiovascular and renal actions of vitamin D and estrogen. Front Biosci (Schol Ed). 2013;5(1):134-48.
6. Gembillo G, Cernaro V, Salvo A, Siligato R, Laudani A, Buemi M, et al. Role of Vitamin D Status in Diabetic Patients with Renal Disease. Medicina (Kaunas). 2019;55(6).
7. Hamano T. Vitamin D and renal outcome: the fourth outcome of CKD-MBD? Oshima Award Address 2015. Clin Exp Nephrol. 2018;22(2):249-56.
8. Icardi A, Paoletti E, De Nicola L, Mazzaferro S, Russo R, Cozzolino M. Renal anaemia and EPO hyporesponsiveness associated with vitamin D deficiency: the potential role of inflammation. Nephrol Dial Transplant. 2013;28(7):1672-9.
9. Khan MI, Bielecka ZF, Najm MZ, Bartnik E, Czarnecki JS, Czarnecka AM, et al. Vitamin D receptor gene polymorphisms in breast and renal cancer: current state and future approaches (review). Int J Oncol. 2014;44(2):349-63.
10. Li L, Wan Q, Yang S, Zhao S. Impact of Vitamin D Receptor Gene Polymorphism on Chronic Renal Failure Susceptibility. Ther Apher Dial. 2018;22(6):575-87.
11. Li YC. Vitamin D receptor signaling in renal and cardiovascular protection. Semin Nephrol. 2013;33(5):433-47.
12. Liu ZM, Woo J, Wu SH, Ho SC. The role of vitamin D in blood pressure, endothelial and renal function in postmenopausal women. Nutrients. 2013;5(7):2590-610.
13. Lucisano S, Buemi M, Passantino A, Aloisi C, Cernaro V, Santoro D. New insights on the role of vitamin D in the progression of renal damage. Kidney Blood Press Res. 2013;37(6):667-78.
14. McGregor R, Li G, Penny H, Lombardi G, Afzali B, Goldsmith DJ. Vitamin D in renal transplantation - from biological mechanisms to clinical benefits. Am J Transplant. 2014;14(6):1259-70.
15. Messa P, Regalia A, Alfieri CM. Nutritional Vitamin D in Renal Transplant Patients: Speculations and Reality. Nutrients. 2017;9(6).
16. Nigwekar SU, Thadhani R. Vitamin D receptor activation: cardiovascular and renal implications. Kidney Int Suppl (2011). 2013;3(5):427-30.
17. Ou C, Zhao HL, Zhu B, Huang LS, Li PZ, Lao M. Association of vitamin D receptor gene polymorphism with the risk of renal cell carcinoma: a meta-analysis. J Recept Signal Transduct Res. 2014;34(6):463-8.
18. Prytuła A, Cransberg K, Raes A. Drug-metabolizing enzymes CYP3A as a link between tacrolimus and vitamin D in renal transplant recipients: is it relevant in clinical practice? Pediatr Nephrol. 2019;34(7):1201-10.
19. Takeuchi Y. [Current Topics on Vitamin D. Treatment of osteoporosis with eldecalcitol: Its therapeutic efficacy and adverse effect on renal function]. Clin Calcium. 2015;25(3):425-32.
20. Yang L, Wu L, Fan Y, Ma J. Associations among four polymorphisms (BsmI, FokI, TaqI and ApaI) of vitamin D receptor gene and end-stage renal disease: a meta-analysis. Arch Med Res. 2015;46(1):1-7.
21. Ando R. [Vitamin D therapy in predialysis renal failure]. Clin Calcium. 2004;14(9):73-7.
22. Bover J, Cozzolino M. Mineral and bone disorders in chronic kidney disease and end-stage renal disease patients: new insights into vitamin D receptor activation. Kidney Int Suppl (2011). 2011;1(4):122-9.
23. Cozzolino M, Bruschetta E, Stucchi A, Ronco C, Cusi D. Role of vitamin d receptor activators in cardio-renal syndromes. Semin Nephrol. 2012;32(1):63-9.
24. Cozzolino M, Gallieni M, Brancaccio D, Arcidiacono T, Bianchi G, Vezzoli G. Vitamin D retains an important role in the pathogenesis and management of secondary hyperparathyroidism in chronic renal failure. J Nephrol. 2006;19(5):566-77.
25. Doorenbos CR, van den Born J, Navis G, de Borst MH. Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism. Nat Rev Nephrol. 2009;5(12):691-700.
26. Drinka PJ. The importance of parathyroid hormone and vitamin D status in the treatment of osteoporosis and renal insufficiency. J Am Med Dir Assoc. 2004;5(6):382-6.
27. Drüeke TB. Which vitamin D derivative to prescribe for renal patients. Curr Opin Nephrol Hypertens. 2005;14(4):343-9.
28. Dusilová Sulková S. [Vitamin D metabolism and current options for therapeutic activation of vitamin D receptor in patients with chronic kidney disease or renal failure]. Vnitr Lek. 2012;58(11):839-49.
29. Dusso A, Arcidiacono MV, Yang J, Tokumoto M. Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality. J Steroid Biochem Mol Biol. 2010;121(1-2):193-8.
30. Dusso AS, Tokumoto M. Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease. Kidney Int. 2011;79(7):715-29.
31. Fukagawa M, Komaba H, Hamano T. Vitamin D supplementation in renal disease: is calcitriol all that is needed? Scand J Clin Lab Invest Suppl. 2012;243:120-3.
32. Hernandez JD, Wesseling K, Salusky IB. Role of parathyroid hormone and therapy with active vitamin D sterols in renal osteodystrophy. Semin Dial. 2005;18(4):290-5.
33. Jones G. Expanding role for vitamin D in chronic kidney disease: importance of blood 25-OH-D levels and extra-renal 1alpha-hydroxylase in the classical and nonclassical actions of 1alpha,25-dihydroxyvitamin D(3). Semin Dial. 2007;20(4):316-24.
34. Levi R, Silver J. Vitamin D supplementation after renal transplantation: how much vitamin D should we prescribe? Kidney Int. 2009;75(6):576-8.
35. Levine BS, Kleeman CR, Felsenfeld AJ. The journey from vitamin D-resistant rickets to the regulation of renal phosphate transport. Clin J Am Soc Nephrol. 2009;4(11):1866-77.
36. Li YC. Vitamin D: roles in renal and cardiovascular protection. Curr Opin Nephrol Hypertens. 2012;21(1):72-9.
37. Melamed ML, Thadhani RI. Vitamin D therapy in chronic kidney disease and end stage renal disease. Clin J Am Soc Nephrol. 2012;7(2):358-65.
38. Negri AL. Proximal tubule endocytic apparatus as the specific renal uptake mechanism for vitamin D-binding protein/25-(OH)D3 complex. Nephrology (Carlton). 2006;11(6):510-5.
39. Richart T, Li Y, Staessen JA. Renal versus extrarenal activation of vitamin D in relation to atherosclerosis, arterial stiffening, and hypertension. Am J Hypertens. 2007;20(9):1007-15.
40. Salusky IB. Are new vitamin D analogues in renal bone disease superior to calcitriol? Pediatr Nephrol. 2005;20(3):393-8.
41. Vervloet MG, Twisk JW. Mortality reduction by vitamin D receptor activation in end-stage renal disease: a commentary on the robustness of current data. Nephrol Dial Transplant. 2009;24(3):703-6.
42. Wetmore JB, Quarles LD. Calcimimetics or vitamin D analogs for suppressing parathyroid hormone in end-stage renal disease: time for a paradigm shift? Nat Clin Pract Nephrol. 2009;5(1):24-33.
43. Wolf M, Thadhani R. Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease. Semin Dial. 2005;18(4):302-6.
44. Wolf M, Thadhani R. Vitamin D in patients with renal failure: a summary of observational mortality studies and steps moving forward. J Steroid Biochem Mol Biol. 2007;103(3-5):487-90.
45. Annweiler C, Schott AM, Berrut G, Chauviré V, Le Gall D, Inzitari M, et al. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010;62(3):139-50.
46. Botella Romero F, Alfaro Martínez JJ, Luna López V, Galicia Martín I. [Enteral nutrition in neurological patients: is there enough vitamin D content in commonly used formulas?]. Nutr Hosp. 2012;27(2):341-8.
47. Di Somma C, Scarano E, Barrea L, Zhukouskaya VV, Savastano S, Mele C, et al. Vitamin D and Neurological Diseases: An Endocrine View. Int J Mol Sci. 2017;18(11).
48. Kaur P, Chakrabarty B. Vitamin D and Neurological Disorders: The Conundrum Continues. Indian J Pediatr. 2019;86(9):771-2.
49. Menéndez SG, Martín Giménez VM, Holick MF, Barrantes FJ, Manucha W. COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agent. Life Sci. 2022;297:120464.
50. Morello M, Pieri M, Zenobi R, Talamo A, Stephan D, Landel V, et al. The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions. Curr Pharm Des. 2020;26(21):2475-91.
51. Moretti R, Morelli ME, Caruso P. Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact. Int J Mol Sci. 2018;19(8).
52. Mpandzou G, Aït Ben Haddou E, Regragui W, Benomar A, Yahyaoui M. Vitamin D deficiency and its role in neurological conditions: A review. Rev Neurol (Paris). 2016;172(2):109-22.
53. Polívka J, Polívka J, Jr., Peterka M, Rohan V, Sevčík P, Topolčan O. [Vitamin D and neurological diseases]. Vnitr Lek. 2012;58(5):393-5.
54. Speer G. [Impact of vitamin D in neurological diseases and neurorehabilitation: from dementia to multiple sclerosis. Part I: the role of vitamin D in the prevention and treatment of multiple sclerosis]. Ideggyogy Sz. 2013;66(9-10):293-303.
55. Ahlawat R, Weinstein T, Pettei MJ. Vitamin D in pediatric gastrointestinal disease. Curr Opin Pediatr. 2017;29(1):122-7.
56. Cai GH, Li MX, Lu L, Yi Chan RL, Wang JH, Cho CH. The current role and therapeutic targets of vitamin D in gastrointestinal inflammation and cancer. Curr Pharm Des. 2015;21(21):2917-23.
57. Cantorna MT, Rogers CJ, Arora J. Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity. Trends Endocrinol Metab. 2019;30(7):459-66.
58. Ferguson LR, Laing B, Marlow G, Bishop K. The role of vitamin D in reducing gastrointestinal disease risk and assessment of individual dietary intake needs: Focus on genetic and genomic technologies. Mol Nutr Food Res. 2016;60(1):119-33.
59. Ghaly S, Lawrance I. The role of vitamin D in gastrointestinal inflammation. Expert Rev Gastroenterol Hepatol. 2014;8(8):909-23.
60. Goyal H, Perisetti A, Rahman MR, Levin A, Lippi G. Vitamin D and Gastrointestinal Cancers: A Narrative Review. Dig Dis Sci. 2019;64(5):1098-109.
61. Li MX, Li LF, Zhang L, Xiao ZG, Shen J, Hu W, et al. Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract. Curr Med Chem. 2017;24(9):918-27.
62. Mahendra A, Karishma, Choudhury BK, Sharma T, Bansal N, Bansal R, et al. Vitamin D and gastrointestinal cancer. J Lab Physicians. 2018;10(1):1-5.
63. Shang M, Sun J. Vitamin D/VDR, Probiotics, and Gastrointestinal Diseases. Curr Med Chem. 2017;24(9):876-87.
64. Trowbridge R, Mittal SK, Agrawal DK. Vitamin D and the epidemiology of upper gastrointestinal cancers: a critical analysis of the current evidence. Cancer Epidemiol Biomarkers Prev. 2013;22(6):1007-14.
65. Bikle DD. Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res. 2007;22 Suppl 2:V50-4.
66. O'Malley T, Heuberger R. Vitamin D status and supplementation in pediatric gastrointestinal disease. J Spec Pediatr Nurs. 2011;16(2):140-50.
67. Pappa HM, Bern E, Kamin D, Grand RJ. Vitamin D status in gastrointestinal and liver disease. Curr Opin Gastroenterol. 2008;24(2):176-83.
68. Achinger SG, Ayus JC. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int Suppl. 2005(95):S37-42.
69. Aleksova A, Janjusevic M, Gagno G, Pierri A, Padoan L, Fluca AL, et al. The Role of Exercise-Induced Molecular Processes and Vitamin D in Improving Cardiorespiratory Fitness and Cardiac Rehabilitation in Patients With Heart Failure. Front Physiol. 2021;12:794641.
70. Fanari Z, Hammami S, Hammami MB, Hammami S, Abdellatif A. Vitamin D deficiency plays an important role in cardiac disease and affects patient outcome: Still a myth or a fact that needs exploration? J Saudi Heart Assoc. 2015;27(4):264-71.
71. Kim IM, Norris KC, Artaza JN. Vitamin D and Cardiac Differentiation. Vitam Horm. 2016;100:299-320.
72. Szabó B, Merkely B, Takács I. [The role of vitamin D in the development of cardiac failure]. Orv Hetil. 2009;150(30):1397-402.
73. Wasserman RH, Brindak ME, Buddle MM, Cai Q, Davis FC, Fullmer CS, et al. Recent studies on the biological actions of vitamin D on intestinal transport and the electrophysiology of peripheral nerve and cardiac muscle. Prog Clin Biol Res. 1990;332:99-126.
74. Wu-Wong JR. Vitamin D therapy in cardiac hypertrophy and heart failure. Curr Pharm Des. 2011;17(18):1794-807.
75. Bergqvist C, Ezzedine K. Vitamin D and the skin: what should a dermatologist know? G Ital Dermatol Venereol. 2019;154(6):669-80.
76. Bikle D, Christakos S. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020;16(4):234-52.
77. Bikle DD. The vitamin D receptor: a tumor suppressor in skin. Adv Exp Med Biol. 2014;810:282-302.
78. Bikle DD. Vitamin D receptor, a tumor suppressor in skin. Can J Physiol Pharmacol. 2015;93(5):349-54.
79. Bikle DD. The Vitamin D Receptor as Tumor Suppressor in Skin. Adv Exp Med Biol. 2020;1268:285-306.
80. Bikle DD, Jiang Y, Nguyen T, Oda Y, Tu CL. Disruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin Cancer. Front Physiol. 2016;7:296.
81. Bikle DD, Oda Y, Tu CL, Jiang Y. Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer. J Steroid Biochem Mol Biol. 2015;148:47-51.
82. Bocheva G, Slominski RM, Slominski AT. The Impact of Vitamin D on Skin Aging. Int J Mol Sci. 2021;22(16).
83. Bolerazska B, Rabajdova M, Spakova I, Marekova M. Current knowledge on the active form of Vitamin D synthesized in the skin and its effects on malignant melanoma. Neoplasma. 2017;64(1):1-12.
84. Burns EM, Elmets CA, Yusuf N. Vitamin D and skin cancer. Photochem Photobiol. 2015;91(1):201-9.
85. Caini S, Gnagnarella P, Stanganelli I, Bellerba F, Cocorocchio E, Queirolo P, et al. Vitamin D and the Risk of Non-Melanoma Skin Cancer: A Systematic Literature Review and Meta-Analysis on Behalf of the Italian Melanoma Intergroup. Cancers (Basel). 2021;13(19).
86. Guo J, Lovegrove JA, Givens DI. A Narrative Review of The Role of Foods as Dietary Sources of Vitamin D of Ethnic Minority Populations with Darker Skin: The Underestimated Challenge. Nutrients. 2019;11(1).
87. Hanel A, Carlberg C. Skin colour and vitamin D: An update. Exp Dermatol. 2020;29(9):864-75.
88. Holick MF. Sunlight, ultraviolet radiation, vitamin D and skin cancer: how much sunlight do we need? Adv Exp Med Biol. 2014;810:1-16.
89. Holick MF. Sunlight, UV Radiation, Vitamin D, and Skin Cancer: How Much Sunlight Do We Need? Adv Exp Med Biol. 2020;1268:19-36.
90. Jones P, Lucock M, Veysey M, Beckett E. The Vitamin D⁻Folate Hypothesis as an Evolutionary Model for Skin Pigmentation: An Update and Integration of Current Ideas. Nutrients. 2018;10(5).
91. Kechichian E, Ezzedine K. Vitamin D and the Skin: An Update for Dermatologists. Am J Clin Dermatol. 2018;19(2):223-35.
92. Khammissa RAG, Fourie J, Motswaledi MH, Ballyram R, Lemmer J, Feller L. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. Biomed Res Int. 2018;2018:9276380.
93. Martin-Gorgojo A, Gilaberte Y, Nagore E. Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review. Nutrients. 2021;13(12).
94. Mostafa WZ, Hegazy RA. Vitamin D and the skin: Focus on a complex relationship: A review. J Adv Res. 2015;6(6):793-804.
95. Navarro-Triviño FJ, Arias-Santiago S, Gilaberte-Calzada Y. Vitamin D and the Skin: A Review for Dermatologists. Actas Dermosifiliogr (Engl Ed). 2019;110(4):262-72.
96. Pawlowska E, Wysokinski D, Blasiak J. Nucleotide Excision Repair and Vitamin D--Relevance for Skin Cancer Therapy. Int J Mol Sci. 2016;17(4):372.
97. Piotrowska A, Wierzbicka J, Żmijewski MA. Vitamin D in the skin physiology and pathology. Acta Biochim Pol. 2016;63(1):17-29.
98. Reichrath J. Solar ultraviolet radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs): an update. Adv Exp Med Biol. 2014;810:253-71.
99. Reichrath J, Rass K. Ultraviolet damage, DNA repair and vitamin D in nonmelanoma skin cancer and in malignant melanoma: an update. Adv Exp Med Biol. 2014;810:208-33.
100. Reichrath J, Saternus R, Vogt T. Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond. Mol Cell Endocrinol. 2017;453:96-102.
101. Reichrath J, Saternus R, Vogt T. Challenge and perspective: the relevance of ultraviolet (UV) radiation and the vitamin D endocrine system (VDES) for psoriasis and other inflammatory skin diseases. Photochem Photobiol Sci. 2017;16(3):433-44.
102. Reichrath J, Zouboulis CC, Vogt T, Holick MF. Targeting the vitamin D endocrine system (VDES) for the management of inflammatory and malignant skin diseases: An historical view and outlook. Rev Endocr Metab Disord. 2016;17(3):405-17.
103. Saternus R, Reichrath J. [Power station sun and hormone factory skin : A current assessment of the importance of vitamin D metabolism during human evolution and strategies for UV prevention]. Hautarzt. 2020;71(10):772-85.
104. Saternus R, Vogt T, Reichrath J. Update: Solar UV Radiation, Vitamin D, and Skin Cancer Surveillance in Organ Transplant Recipients (OTRs). Adv Exp Med Biol. 2020;1268:335-53.
105. Slominski AT, Brożyna AA, Zmijewski MA, Janjetovic Z, Kim TK, Slominski RM, et al. The Role of Classical and Novel Forms of Vitamin D in the Pathogenesis and Progression of Nonmelanoma Skin Cancers. Adv Exp Med Biol. 2020;1268:257-83.
106. Stewart AE, Roecklein KA, Tanner S, Kimlin MG. Possible contributions of skin pigmentation and vitamin D in a polyfactorial model of seasonal affective disorder. Med Hypotheses. 2014;83(5):517-25.
107. Tongkao-On W, Carter S, Reeve VE, Dixon KM, Gordon-Thomson C, Halliday GM, et al. CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds. J Steroid Biochem Mol Biol. 2015;148:72-8.
108. Toniato E, Spinas E, Saggini A, Kritas SK, Caraffa A, Antinolfi P, et al. IMMUNOMODULATORY EFFECTS OF VITAMIN D ON SKIN INFLAMMATION. J Biol Regul Homeost Agents. 2015;29(3):563-7.
109. Umar M, Sastry KS, Al Ali F, Al-Khulaifi M, Wang E, Chouchane AI. Vitamin D and the Pathophysiology of Inflammatory Skin Diseases. Skin Pharmacol Physiol. 2018;31(2):74-86.
110. Vishlaghi N, Lisse TS. Exploring vitamin D signalling within skin cancer. Clin Endocrinol (Oxf). 2020;92(4):273-81.
111. Wadhwa B, Relhan V, Goel K, Kochhar AM, Garg VK. Vitamin D and skin diseases: A review. Indian J Dermatol Venereol Leprol. 2015;81(4):344-55.
112. Wolf ST, Kenney WL. Skin pigmentation and vitamin D-folate interactions in vascular function: an update. Curr Opin Clin Nutr Metab Care. 2021;24(6):528-35.
113. Wyatt C, Neale RE, Lucas RM. Skin cancer and vitamin D: an update. Melanoma Manag. 2015;2(1):51-61.
114. Xiang F, Lucas R, de Gruijl F, Norval M. A systematic review of the influence of skin pigmentation on changes in the concentrations of vitamin D and 25-hydroxyvitamin D in plasma/serum following experimental UV irradiation. Photochem Photobiol Sci. 2015;14(12):2138-46.
115. Askari G, Rafie N, Miraghajani M, Heidari Z, Arab A. Association between vitamin D and dry eye disease: A systematic review and meta-analysis of observational studies. Cont Lens Anterior Eye. 2020;43(5):418-25.
116. Bae SH, Shin YJ, Kim HK, Hyon JY, Wee WR, Park SG. Vitamin D Supplementation for Patients with Dry Eye Syndrome Refractory to Conventional Treatment. Sci Rep. 2016;6:33083.
117. Demirci G, Karaman Erdur S, Ozsutcu M, Eliacik M, Olmuscelik O, Aydin R, et al. Dry Eye Assessment in Patients With Vitamin D Deficiency. Eye Contact Lens. 2018;44 Suppl 1:S62-s5.
118. Eslampoor A, Najjaran M, Arjmand Askari E, Zarei-Ghanavati S, Ziaei M. Effect of oral vitamin D supplementation on dry eye disease patients with vitamin D deficiency. Clin Exp Optom. 2022:1-6.
119. Galor A, Gardener H, Pouyeh B, Feuer W, Florez H. Effect of a Mediterranean dietary pattern and vitamin D levels on Dry Eye syndrome. Cornea. 2014;33(5):437-41.
120. Heisel CJ, Riddering AL, Andrews CA, Kahana A. Serum Vitamin D Deficiency Is an Independent Risk Factor for Thyroid Eye Disease. Ophthalmic Plast Reconstr Surg. 2020;36(1):17-20.
121. Hwang JS, Lee YP, Shin YJ. Vitamin D Enhances the Efficacy of Topical Artificial Tears in Patients With Dry Eye Disease. Cornea. 2019;38(3):304-10.
122. Jain N, Sharma P, Chouhan JK. A study of the association between Vitamin D deficiency and Dry Eye Syndrome (DES) in the Indian population. Indian J Ophthalmol. 2022;70(2):500-4.
123. Jee D, Kang S, Yuan C, Cho E, Arroyo JG. Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases. PLoS One. 2016;11(2):e0149294.
124. Jeon DH, Yeom H, Yang J, Song JS, Lee HK, Kim HC. Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease. J Prev Med Public Health. 2017;50(6):369-76.
125. Jin KW, Ro JW, Shin YJ, Hyon JY, Wee WR, Park SG. Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome. Acta Ophthalmol. 2017;95(3):e230-e5.
126. Khamar P, Nair AP, Shetty R, Vaidya T, Subramani M, Ponnalagu M, et al. Dysregulated Tear Fluid Nociception-Associated Factors, Corneal Dendritic Cell Density, and Vitamin D Levels in Evaporative Dry Eye. Invest Ophthalmol Vis Sci. 2019;60(7):2532-42.
127. Kuo CY, Huang YC, Lin KJ, Tsai TY. Vitamin D Deficiency Is Associated with Severity of Dry Eye Symptoms and Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis. J Nutr Sci Vitaminol (Tokyo). 2020;66(4):386-8.
128. Kurtul BE, Özer PA, Aydinli MS. The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye. Eye (Lond). 2015;29(8):1081-4.
129. Lee JH, Kim SJ, Byun YS, Lee J, Park SH, Chung SH. The Association of Serum Vitamin D Level With the Severity of Dry Eye Parameters in Primary Sjögren Syndrome. Cornea. 2020;39(6):702-5.
130. Lin Y, Ubels JL, Schotanus MP, Yin Z, Pintea V, Hammock BD, et al. Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. Curr Eye Res. 2012;37(10):871-8.
131. Liu J, Dong Y, Wang Y. Vitamin D deficiency is associated with dry eye syndrome: a systematic review and meta-analysis. Acta Ophthalmol. 2020;98(8):749-54.
132. McKay GJ, Young IS, McGinty A, Bentham GC, Chakravarthy U, Rahu M, et al. Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study. Ophthalmology. 2017;124(1):90-6.
133. McMillan J. Spectrum of Darkness, Agent of Light: Myopia, Keratoconus, Ocular Surface Disease, and Evidence for a Profoundly Vitamin D-dependent Eye. Cureus. 2018;10(6):e2744.
134. Meng YF, Lu J, Xing Q, Tao JJ, Xiao P. Lower Serum Vitamin D Level Was Associated with Risk of Dry Eye Syndrome. Med Sci Monit. 2017;23:2211-6.
135. Meng YF, Xin Q, Lu J, Xiao P, Li J. Association Between Single Nucleotide Polymorphisms in the Vitamin D Receptor and Incidence of Dry Eye Disease in Chinese Han Population. Med Sci Monit. 2019;25:4759-65.
136. Nandyala S, Mohamed A, Bhargava A, Chaurasia S, Senthil S, Vaddavalli PK. Vitamin D deficiency in healthcare professionals across the network of an eye care organization in India. Indian J Ophthalmol. 2021;69(2):455-6.
137. Rullo J, Pennimpede T, Mehraban Far P, Strube YN, Irrcher I, Urton T, et al. Intraocular calcidiol: Uncovering a role for vitamin D in the eye. J Steroid Biochem Mol Biol. 2020;197:105536.
138. Sadaka A, Nguyen K, Malik A, Brito R, Berry S, Lee AG. Vitamin D and Selenium in a Thyroid Eye Disease Population in Texas. Neuroophthalmology. 2019;43(5):291-4.
139. Shetty R, Deshpande K, Deshmukh R, Jayadev C, Shroff R. Bowman Break and Subbasal Nerve Plexus Changes in a Patient With Dry Eye Presenting With Chronic Ocular Pain and Vitamin D Deficiency. Cornea. 2016;35(5):688-91.
140. Shetty R, Sethu S, Chevour P, Deshpande K, Pahuja N, Nagaraja H, et al. Lower Vitamin D Level and Distinct Tear Cytokine Profile Were Observed in Patients with Mild Dry Eye Signs but Exaggerated Symptoms. Transl Vis Sci Technol. 2016;5(6):16.
141. Shetty R, Sethu S, Deshmukh R, Deshpande K, Ghosh A, Agrawal A, et al. Corneal Dendritic Cell Density Is Associated with Subbasal Nerve Plexus Features, Ocular Surface Disease Index, and Serum Vitamin D in Evaporative Dry Eye Disease. Biomed Res Int. 2016;2016:4369750.
142. Sridhar U, Tripathy K. Commentary: Dry eye syndrome and vitamin D deficiency. Indian J Ophthalmol. 2020;68(6):1026-7.
143. Watts P, Sahai A, Kumar PR, Shamshad MA, Trivedi GK, Tyagi L. A prospective study to assess the role of vitamin D individually and in combination with cyclosporine in the treatment of dry eye in patients with deficient serum 25(OH)D levels. Indian J Ophthalmol. 2020;68(6):1020-6.
144. Yang CH, Albietz J, Harkin DG, Kimlin MG, Schmid KL. Impact of oral vitamin D supplementation on the ocular surface in people with dry eye and/or low serum vitamin D. Cont Lens Anterior Eye. 2018;41(1):69-76.
145. Yildirim P, Garip Y, Karci AA, Guler T. Dry eye in vitamin D deficiency: more than an incidental association. Int J Rheum Dis. 2016;19(1):49-54.
146. Zhang J, Dai Y, Wu D, Xu J. Calcitriol, the Active Metabolite of Vitamin D(3), Inhibits Dry Eye Related Corneal Inflammation In Vivo and In Vitro. Ocul Immunol Inflamm. 2019;27(2):257-65.
147. Abhimanyu, Coussens AK. The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease. Photochem Photobiol Sci. 2017;16(3):314-38.
148. Alitalo A. [Human anti-infectious defence may be enhanced by vitamin D]. Duodecim. 2010;126(10):1127-34.
149. Amado CA, García-Unzueta MT, Fariñas MC, Santos F, Ortiz M, Muñoz-Cacho P, et al. Vitamin D nutritional status and vitamin D regulated antimicrobial peptides in serum and pleural fluid of patients with infectious and noninfectious pleural effusions. BMC Pulm Med. 2016;16(1):99.
150. Camargo CA, Jr., Manson JE. Vitamin D supplementation and risk of infectious disease: no easy answers. Am J Clin Nutr. 2014;99(1):3-4.
151. Chesney RW. Vitamin D and The Magic Mountain: the anti-infectious role of the vitamin. J Pediatr. 2010;156(5):698-703.
152. Chonchol M, Greene T, Zhang Y, Hoofnagle AN, Cheung AK. Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study. J Am Soc Nephrol. 2016;27(1):227-37.
153. Dini C, Bianchi A. The potential role of vitamin D for prevention and treatment of tuberculosis and infectious diseases. Ann Ist Super Sanita. 2012;48(3):319-27.
154. Garner KM, Zavala S, Pape KO, Walroth T, Reger M, Thomas W, et al. A multicenter study analyzing the association of vitamin D deficiency and replacement with infectious outcomes in patients with burn injuries. Burns. 2021.
155. Ghosn J, Viard JP. [Vitamin D and infectious diseases]. Presse Med. 2013;42(10):1371-6.
156. Gois PHF, Ferreira D, Olenski S, Seguro AC. Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? Nutrients. 2017;9(7).
157. Jaime J, Vargas-Bermúdez DS, Yitbarek A, Reyes J, Rodríguez-Lecompte JC. Differential immunomodulatory effect of vitamin D (1,25 (OH)(2) D(3)) on the innate immune response in different types of cells infected in vitro with infectious bursal disease virus. Poult Sci. 2020;99(9):4265-77.
158. Kearns MD, Alvarez JA, Seidel N, Tangpricha V. Impact of vitamin D on infectious disease. Am J Med Sci. 2015;349(3):245-62.
159. Liao SL, Lai SH, Tsai MH, Hua MC, Yeh KW, Su KW, et al. Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy. Mediators Inflamm. 2016;2016:8175898.
160. Maghzi H, Ataei B, Khorvash F, Yaran M, Maghzi AH. Association Between Acute Infectious Mononucleosis and Vitamin D Deficiency. Viral Immunol. 2016;29(7):398-400.
161. Miragliotta G, Miragliotta L. Vitamin D and infectious diseases. Endocr Metab Immune Disord Drug Targets. 2014;14(4):267-71.
162. Moran-Lev H, Weisman Y, Cohen S, Deutsch V, Cipok M, Bondar E, et al. The interrelationship between hepcidin, vitamin D, and anemia in children with acute infectious disease. Pediatr Res. 2018;84(1):62-5.
163. Park SW, Lee YJ, Ryoo E. Difference in Vitamin D Levels Between Children with Clostridioides difficile Enteritis and Those with Other Acute Infectious Enteritis. Pediatr Gastroenterol Hepatol Nutr. 2021;24(1):81-9.
164. Platitsyna NG, Bolotnova TV. [Vitamin D deficiency as a risk factor for chronic non-infectious diseases.]. Adv Gerontol. 2017;30(6):873-9.
165. Sun Q, Gao Y, Qiao L, Yuan Y, Liu Q. 25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFβ-mediated nuclear translocation mechanism of YAP/TAZ. Bioengineered. 2021;12(1):8931-42.
166. Turan A, Artis AS, Hanline C, Saha P, Maheshwari K, Kurz A, et al. Preoperative Vitamin D Concentration and Cardiac, Renal, and Infectious Morbidity after Noncardiac Surgery. Anesthesiology. 2020;132(1):121-30.
167. Van Belle TL, Gysemans C, Mathieu C. Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Best Pract Res Clin Endocrinol Metab. 2011;25(4):617-32.
168. Vassiliou AG, Jahaj E, Orfanos SE, Dimopoulou I, Kotanidou A. Vitamin D in infectious complications in critically ill patients with or without COVID-19. Metabol Open. 2021;11:100106.
169. Watkins RR, Lemonovich TL, Salata RA. An update on the association of vitamin D deficiency with common infectious diseases. Can J Physiol Pharmacol. 2015;93(5):363-8.
170. Watts KM, Lahiri P, Arrazuria R, De Buck J, Knight CG, Orsel K, et al. Oxytetracycline reduces inflammation and treponeme burden whereas vitamin D(3) promotes β-defensin expression in bovine infectious digital dermatitis. Cell Tissue Res. 2020;379(2):337-48.
171. Weiss ST, Litonjua AA. Vitamin D dosing for infectious and immune disorders. Thorax. 2015;70(10):919-20.
172. White JH. Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun. 2008;76(9):3837-43.
173. Yamshchikov AV, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V. Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials. Endocr Pract. 2009;15(5):438-49.
174. Zisi D, Challa A, Makis A. The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood. Hormones (Athens). 2019;18(4):353-63.
175. al-Aqeel A, Ozand P, Sobki S, Sewairi W, Marx S. The combined use of intravenous and oral calcium for the treatment of vitamin D dependent rickets type II (VDDRII). Clin Endocrinol (Oxf). 1993;39(2):229-37.
176. Andress DL. Intravenous versus oral vitamin d therapy in dialysis patients: what is the question? Am J Kidney Dis. 2001;38(5 Suppl 5):S41-4.
177. Argilés A, Mourad G, Mion C. Oral vitamin D or calcium carbonate in the prevention of renal bone disease? Curr Opin Nephrol Hypertens. 1996;5(4):329-36.
178. Arman S. What are the effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age? - A Cochrane Review summary with commentary. J Musculoskelet Neuronal Interact. 2021;21(3):447-50.
179. Biondi P, Pepe J, Biamonte F, Occhiuto M, Parisi M, Demofonti C, et al. Oral calcidiol is a good form of vitamin D supplementation. Clin Cases Miner Bone Metab. 2017;14(2):207-8.
180. Bischoff-Ferrari HA. Which vitamin D oral supplement is best for postmenopausal women? Curr Osteoporos Rep. 2012;10(4):251-7.
181. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 2009;169(6):551-61.
182. Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ. Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients. 2020;12(5).
183. Diachkova E, Trifonova D, Morozova E, Runova G, Ashurko I, Ibadulaeva M, et al. Vitamin D and Its Role in Oral Diseases Development. Scoping Review. Dent J (Basel). 2021;9(11).
184. El-Hamd MA, El Taieb MA, Ibrahim HM, Aly SS. Vitamin D levels in acne vulgaris patients treated with oral isotretinoin. J Cosmet Dermatol. 2019;18(1):16-20.
185. Fathi N, Ahmadian E, Shahi S, Roshangar L, Khan H, Kouhsoltani M, et al. Role of vitamin D and vitamin D receptor (VDR) in oral cancer. Biomed Pharmacother. 2019;109:391-401.
186. Girgis E, Reyad AA. Vitamin D: Pharmacology and Clinical Challenges in Oral Health Care. J Int Acad Periodontol. 2019;21(3):118-24.
187. Glade MJ. A 21st century evaluation of the safety of oral vitamin D. Nutrition. 2012;28(4):344-56.
188. Grant WB, Garland CF, Gorham ED. An estimate of cancer mortality rate reductions in Europe and the US with 1,000 IU of oral vitamin D per day. Recent Results Cancer Res. 2007;174:225-34.
189. Grant WB, Moukayed M. Vitamin D(3) from Ultraviolet-B Exposure or Oral Intake in Relation to Cancer Incidence and Mortality. Curr Nutr Rep. 2019;8(3):203-11.
190. Kamangar F, Koo J, Heller M, Lee E, Bhutani T. Oral vitamin D, still a viable treatment option for psoriasis. J Dermatolog Treat. 2013;24(4):261-7.
191. Kearns MD, Alvarez JA, Tangpricha V. Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review. Endocr Pract. 2014;20(4):341-51.
192. Khammissa RAG, Ballyram R, Jadwat Y, Fourie J, Lemmer J, Feller L. Vitamin D Deficiency as It Relates to Oral Immunity and Chronic Periodontitis. Int J Dent. 2018;2018:7315797.
193. Lucas RM, Ponsonby AL. Considering the potential benefits as well as adverse effects of sun exposure: can all the potential benefits be provided by oral vitamin D supplementation? Prog Biophys Mol Biol. 2006;92(1):140-9.
194. Mangan A, Le Roux CW, Miller NG, Docherty NG. Iron and Vitamin D/Calcium Deficiency after Gastric Bypass: Mechanisms Involved and Strategies to Improve Oral Supplement Disposition. Curr Drug Metab. 2019;20(3):244-52.
195. Mazess RB, Elangovan L. A review of intravenous versus oral vitamin D hormone therapy in hemodialysis patients. Clin Nephrol. 2003;59(5):319-25.
196. McCullough PJ, McCullough WP, Lehrer D, Travers JB, Repas SJ. Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-Hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications. Nutrients. 2021;13(5).
197. Mumena CH, Mudhihiri MH, Sasi R, Mlawa M, Nyerembe S, Akimbekov NS, et al. The relevance of vitamin D in the oral health of HIV infected patients. J Steroid Biochem Mol Biol. 2021;211:105905.
198. Peersman G, Bellemans J, Richart T. Is oral vitamin D a risk factor for prosthetic loosening? Acta Orthop Belg. 2009;75(1):2-7.
199. Ślebioda Z, Szponar E, Dorocka-Bobkowska B. Vitamin D and Its Relevance in the Etiopathogenesis of Oral Cavity Diseases. Arch Immunol Ther Exp (Warsz). 2016;64(5):385-97.
200. Stanescu AMA, Simionescu AA, Diaconu CC. Oral Vitamin D Therapy in Patients with Psoriasis. Nutrients. 2021;13(1).
201. Stein SH, Tipton DA. Vitamin D and its impact on oral health--an update. J Tenn Dent Assoc. 2011;91(2):30-3; quiz 4-5.
202. Theodoridis X, Grammatikopoulou MG, Stamouli EM, Talimtzi P, Pagkalidou E, Zafiriou E, et al. Effectiveness of oral vitamin D supplementation in lessening disease severity among patients with psoriasis: A systematic review and meta-analysis of randomized controlled trials. Nutrition. 2021;82:111024.
203. Uwitonze AM, Murererehe J, Ineza MC, Harelimana EI, Nsabimana U, Uwambaye P, et al. Effects of vitamin D status on oral health. J Steroid Biochem Mol Biol. 2018;175:190-4.
204. Uwitonze AM, Rahman S, Ojeh N, Grant WB, Kaur H, Haq A, et al. Oral manifestations of magnesium and vitamin D inadequacy. J Steroid Biochem Mol Biol. 2020;200:105636.
205. Xing T, Hu Y, Wang B, Zhu J. Role of oral calcium supplementation alone or with vitamin D in preventing post-thyroidectomy hypocalcaemia: A meta-analysis. Medicine (Baltimore). 2019;98(8):e14455.
206. Zanetta P, Squarzanti DF, Sorrentino R, Rolla R, Aluffi Valletti P, Garzaro M, et al. Oral microbiota and vitamin D impact on oropharyngeal squamous cell carcinogenesis: a narrative literature review. Crit Rev Microbiol. 2021;47(2):224-39.
207. Bittker SS, Bell KR. Acetaminophen, antibiotics, ear infection, breastfeeding, vitamin D drops, and autism: an epidemiological study. Neuropsychiatr Dis Treat. 2018;14:1399-414.
208. Büki B, Jünger H, Zhang Y, Lundberg YW. The Price of Immune Responses and the Role of Vitamin D in the Inner Ear. Otol Neurotol. 2019;40(6):701-9.
209. Komina-Kosolapova VP. [Trophic changes in the bony capsule of the ear labyrinth and in the auditory ossicles in rabbits under the influence of vitamin D and parathyrocrine]. Biull Eksp Biol Med. 1965;60(12):98-101.
210. Kwon HJ. Vitamin D receptor deficiency impairs inner ear development in zebrafish. Biochem Biophys Res Commun. 2016;478(2):994-8.
211. Li Y, Xu Z, Zhang L, Quan C, Lin X. [Detection and correlation of lipopolysaccharide, vitamin D receptor and matrix metalloproteinase-9 in the middle ear cholesteatoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012;26(16):739-41, 46.
212. Palframan KM, Robinson SL, Mora-Plazas M, Marin C, Villamor E. Vitamin D-binding protein is inversely associated with the incidence of gastrointestinal and ear infections in school-age children. Epidemiol Infect. 2018;146(15):1996-2002.
213. Thornton KA, Marín C, Mora-Plazas M, Villamor E. Vitamin D deficiency associated with increased incidence of gastrointestinal and ear infections in school-age children. Pediatr Infect Dis J. 2013;32(6):585-93.
214. Xu Z, Meenu M, Xu B. Effects of UV-C treatment and ultrafine-grinding on the biotransformation of ergosterol to vitamin D(2), physiochemical properties, and antioxidant properties of shiitake and Jew's ear. Food Chem. 2020;309:125738.
215. New developments in pharmacology of vitamin D. Med Lett Drugs Ther. 1974;16(3):15-6.
216. The pharmacology of vitamins and beyond. Part 1: Vitamin D. Can J Physiol Pharmacol. 2015;93(5):v.
217. Campbell PA, Young MW, Lee RC. Vitamin D Clinical Pharmacology: Relevance to COVID-19 Pathogenesis. J Natl Med Assoc. 2021;113(2):208-11.
218. Fan P, Qi X, Sweet RA, Wang L. Network Systems Pharmacology-Based Mechanism Study on the Beneficial Effects of Vitamin D against Psychosis in Alzheimer's Disease. Sci Rep. 2020;10(1):6136.
219. Kang S, Li XY, Voorhees JJ. Pharmacology and molecular action of retinoids and vitamin D in skin. J Investig Dermatol Symp Proc. 1996;1(1):15-21.
220. Li S, Wang Y, Zhang C. Network pharmacology strategy for predicting the correlation of Systemic Scleroderma with Vitamin D deficiency. Int Immunopharmacol. 2020;86:106702.
221. Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, et al. International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev. 2006;58(4):742-59.
222. Pierides AM. Pharmacology and therapeutic use of vitamin D and its analogues. Drugs. 1981;21(4):241-56.
223. Pihl TH, Jørgensen CS, Santoni-Rugiu E, Leifsson PS, Hansen EW, Laursen I, et al. Safety pharmacology, toxicology and pharmacokinetic assessment of human Gc globulin (vitamin D binding protein). Basic Clin Pharmacol Toxicol. 2010;107(5):853-60.
224. Plourde V, Haddad P, Gascon-Barré M, D'Amour P. [Vitamin D and the pharmacology of anomalies of phospho-calcium homeostasis. General review]. Union Med Can. 1987;116(2):89-96.
225. Wu Y, Wang Y, Liu X, Jiang L, Guli A, Sailike J, et al. Ziziphora clinopodioides flavonoids based on network pharmacology attenuates atherosclerosis in rats induced by high-fat emulsion combined with vitamin D(3) by down-regulating VEGF/AKT/NF-κB signaling pathway. Biomed Pharmacother. 2020;129:110399.
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